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An epigenetic therapy for diffuse intrinsic pontine gliomas

Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.

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Figure 1: The H3.1 K27M altered chromatin state is reversible by JMJD3 inhibition.

Katie Vicari/Nature Publishing Group

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Correspondence to Michael D Taylor.

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Ramaswamy, V., Remke, M. & Taylor, M. An epigenetic therapy for diffuse intrinsic pontine gliomas. Nat Med 20, 1378–1379 (2014). https://doi.org/10.1038/nm.3769

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