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MicroRNA-124 modulates social behavior in frontotemporal dementia

Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.

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Figure 1: FTD is associated with deficits in social behavior.

Katie Vicari/Nature Publishing Group

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Correspondence to Erik D Roberson.

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Arrant, A., Roberson, E. MicroRNA-124 modulates social behavior in frontotemporal dementia. Nat Med 20, 1381–1383 (2014). https://doi.org/10.1038/nm.3768

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