Truncation of tau contributes to the formation of neurofibrillary tangles in Alzheimer's disease. A new study finds a direct role for a lysosomal cysteine protease, asparagine endopeptidase, in cleaving tau into neurotoxic fragments.
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Rosenmann, H. Asparagine endopeptidase cleaves tau and promotes neurodegeneration. Nat Med 20, 1236–1238 (2014). https://doi.org/10.1038/nm.3749
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DOI: https://doi.org/10.1038/nm.3749
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