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Osteoclast progenitors promote bone vascularization and osteogenesis

Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.

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Figure 1: POCs are precursors of bone-degrading osteoclasts.

Katie Vicari/Nature Publishing Group


  1. Maes, C. et al. Dev. Cell 19, 329–344 (2010).

    Article  CAS  Google Scholar 

  2. Kusumbe, A.P., Ramasamy, S.K. & Adams, R.H. Nature 507, 323–328 (2014).

    Article  CAS  Google Scholar 

  3. Ramasamy, S.K., Kusumbe, A.P., Wang, L. & Adams, R.H. Nature 507, 376–380 (2014).

    Article  CAS  Google Scholar 

  4. Xie, H. et al. Nat. Med. 20, 1270–1278 (2014).

    Article  CAS  Google Scholar 

  5. Kreja, L. et al. J. Cell. Biochem. 109, 347–355 (2010).

    CAS  PubMed  Google Scholar 

  6. Sanchez-Fernandez, M.A. et al. PLoS ONE 3, e3537 (2008).

    Article  Google Scholar 

  7. Andrae, J., Gallini, R. & Betsholtz, C. Genes Dev. 22, 1276–1312 (2008).

    Article  CAS  Google Scholar 

  8. Ball, S.G., Shuttleworth, C.A. & Kielty, C.M. J. Cell. Mol. Med. 11, 1012–1030 (2007).

    Article  CAS  Google Scholar 

  9. Olsson, A.K. Dimberg, A., Kreuger, J. & Claesson-Welsh, L. Nat. Rev. Mol. Cell Biol. 7, 359–371 (2006).

    Article  CAS  Google Scholar 

  10. Richardson, M.R. & Yoder, M.C. 50, 266–272 (2011).

  11. Mendelson, K., Evans, T. & Hla, T. Development 141, 5–9 (2014).

    Article  CAS  Google Scholar 

  12. Ryu, J. et al. EMBO J. 25, 5840–5851 (2006).

    Article  CAS  Google Scholar 

  13. Saftig, P. et al. Proc. Natl. Acad. Sci. USA 95, 13453–13458 (1998).

    Article  CAS  Google Scholar 

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Correspondence to Ralf H. Adams.

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Kusumbe, A., Adams, R. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med 20, 1238–1240 (2014).

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