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Megakaryocytes in the hematopoietic stem cell niche


Mesenchymal stromal cells are key components of hematopoietic stem cell (HSC) niches in the bone marrow. Two studies now show that hematopoietic-derived megakaryocytes also contribute to the HSC niche, regulating HSC quiescence and function.

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Figure 1: The majority of HSCs are perivascular, localizing to either arteriolar or sinusoidal niches, which consist of a number of different nonhematopoietic stromal cell types.

Katie Vicari/Nature Publishing Group


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Correspondence to Daniel C. Link.

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Day, R., Link, D. Megakaryocytes in the hematopoietic stem cell niche. Nat Med 20, 1233–1234 (2014).

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