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Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing

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References

  1. Dienstmann, R. et al. Mol. Oncol. 8, 859–873 (2014).

    Article  Google Scholar 

  2. Kumar, P., Henikoff, S. & Ng, P.C. Nat. Protoc. 4, 1073–1081 (2009).

    Article  CAS  Google Scholar 

  3. Adzhubei, I.A. et al. Nat. Methods 7, 248–249 (2010).

    Article  CAS  Google Scholar 

  4. Donnelly, P. Nature 456, 728–731 (2008).

    Article  CAS  Google Scholar 

  5. Sander, J.D. & Joung, J.K. Nat. Biotechnol. 32, 347–355 (2014).

    Article  CAS  Google Scholar 

  6. Jinek, M. et al. Science 337, 816–821 (2012).

    Article  CAS  Google Scholar 

  7. Xue, W. et al. Nature 10.1038/nature13589 (6 August 2014).

  8. Smurnyy, Y. et al. Nat. Chem. Biol. 10, 623–625 (2014).

    Article  CAS  Google Scholar 

  9. Wang, H. et al. Cell 153, 910–918 (2013).

    Article  CAS  Google Scholar 

  10. Tsai, S.Q. et al. Nat. Biotechnol. 32, 569–576 (2014).

    Article  CAS  Google Scholar 

  11. Heckl, D. et al. Nat. Biotechnol. 32, 941–946 (2014).

    Article  CAS  Google Scholar 

  12. Tang, Q. et al. Nat. Methods 11, 821–824 (2014).

    Article  CAS  Google Scholar 

  13. Fu, Y. et al. Nat. Biotechnol. 31, 822–826 (2013).

    Article  CAS  Google Scholar 

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Correspondence to J Keith Joung.

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Competing interests

J.K.J. is a consultant for Horizon Discovery. J.K.J. has financial interests in Editas Medicine and Transposagen Biopharmaceuticals. J.K.J.'s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.

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Tsai, S., Iafrate, A. & Joung, J. Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing. Nat Med 20, 1103–1104 (2014). https://doi.org/10.1038/nm.3722

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