Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing

Subjects

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1

References

  1. Dienstmann, R. et al. Mol. Oncol. 8, 859–873 (2014).

    Article  Google Scholar 

  2. Kumar, P., Henikoff, S. & Ng, P.C. Nat. Protoc. 4, 1073–1081 (2009).

    CAS  Article  Google Scholar 

  3. Adzhubei, I.A. et al. Nat. Methods 7, 248–249 (2010).

    CAS  Article  Google Scholar 

  4. Donnelly, P. Nature 456, 728–731 (2008).

    CAS  Article  Google Scholar 

  5. Sander, J.D. & Joung, J.K. Nat. Biotechnol. 32, 347–355 (2014).

    CAS  Article  Google Scholar 

  6. Jinek, M. et al. Science 337, 816–821 (2012).

    CAS  Article  Google Scholar 

  7. Xue, W. et al. Nature 10.1038/nature13589 (6 August 2014).

  8. Smurnyy, Y. et al. Nat. Chem. Biol. 10, 623–625 (2014).

    CAS  Article  Google Scholar 

  9. Wang, H. et al. Cell 153, 910–918 (2013).

    CAS  Article  Google Scholar 

  10. Tsai, S.Q. et al. Nat. Biotechnol. 32, 569–576 (2014).

    CAS  Article  Google Scholar 

  11. Heckl, D. et al. Nat. Biotechnol. 32, 941–946 (2014).

    CAS  Article  Google Scholar 

  12. Tang, Q. et al. Nat. Methods 11, 821–824 (2014).

    CAS  Article  Google Scholar 

  13. Fu, Y. et al. Nat. Biotechnol. 31, 822–826 (2013).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J Keith Joung.

Ethics declarations

Competing interests

J.K.J. is a consultant for Horizon Discovery. J.K.J. has financial interests in Editas Medicine and Transposagen Biopharmaceuticals. J.K.J.'s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tsai, S., Iafrate, A. & Joung, J. Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing. Nat Med 20, 1103–1104 (2014). https://doi.org/10.1038/nm.3722

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3722

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing