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Protein breakdown precedes pancreatic tumor development

A new study shows that plasma levels of branched-chain amino acids are elevated in subjects several years before they are diagnosed with pancreatic cancer. This may reflect breakdown of peripheral protein stores in the early stages of the disease.

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Figure 1: Early pancreatic cancer is associated with changes in circulating amino acids.

Katie Vicari/Nature Publishing Group

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Correspondence to Kenneth P. Olive.

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Holmstrom, S., Olive, K. Protein breakdown precedes pancreatic tumor development. Nat Med 20, 1097–1099 (2014). https://doi.org/10.1038/nm.3714

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