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Thymocyte transformation enhanced

A new study identifies recurrent somatic duplications of a NOTCH1-driven enhancer of MYC in human T cell leukemia. This enhancer is required for both normal and malignant T cell development.

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Figure 1: The NOTCH1-bound MYC enhancer (N-Me) is required for normal and malignant T cell development.

Katie Vicari/Nature Publishing Group

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Correspondence to Alejandro Gutierrez.

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Pouliot, G., Gutierrez, A. Thymocyte transformation enhanced. Nat Med 20, 1096–1097 (2014). https://doi.org/10.1038/nm.3711

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