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Inhibiting Janus kinases to treat alopecia areata

Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.

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Figure 1: Positive feedback loop in AA.

Debbie Maizels/Nature Publishing Group


  1. Gilhar, A., Etzioni, A. & Paus, R. N. Engl. J. Med. 366, 1515–1525 (2012).

    Article  CAS  Google Scholar 

  2. Xing, L. et al. Nat. Med. 20, 1043–1049 (2014).

    Article  CAS  Google Scholar 

  3. Sundberg, J.P., Cordy, W.R. & King, L.E. Jr. J. Invest. Dermatol. 102, 847–856 (1994).

    Article  CAS  Google Scholar 

  4. McElwee, K.J., Boggess, D., King, L.E. Jr. & Sundberg, J.P. J. Invest. Dermatol. 111, 797–803 (1998).

    Article  CAS  Google Scholar 

  5. Sundberg, J.P., Silva, K.A., Li, R., Cox, G.A. & King, L.E. J. Invest. Dermatol. 123, 294–297 (2004).

    Article  CAS  Google Scholar 

  6. McElwee, K.J. et al. Pathobiology 66, 90–107 (1998).

    Article  CAS  Google Scholar 

  7. Petukhova, L. et al. Nature 466, 113–117 (2010).

    Article  CAS  Google Scholar 

  8. Gilhar, A., Kam, Y., Assy, B. & Kalish, R.S. J. Invest. Dermatol. 124, 288–289 (2005).

    Article  Google Scholar 

  9. Freyschmidt-Paul, P. et al. Br. J. Dermatol. 155, 515–521 (2006).

    Article  CAS  Google Scholar 

  10. Brajac, I., Gruber, F., Petrovecki, M. & Malnar-Dragojevic, D. Acta Dermatovenerol. Croat. 12, 154–156 (2004).

    PubMed  Google Scholar 

  11. Weng, N.P., Liu, K., Catalfamo, M., Li, Y. & Henkart, P.A. Ann. NY Acad. Sci. 975, 46–56 (2002).

    Article  CAS  Google Scholar 

  12. Spolski, R. & Leonard, W.J. Nat. Rev. Drug Discov. 13, 379–395 (2014).

    Article  CAS  Google Scholar 

  13. Craiglow, B.G. & King, B.A. J. Invest. Dermatol. doi:10.1038/jid.2014.260 (17 July 2014).

    Article  CAS  Google Scholar 

  14. Quintás-Cardama, A. et al. Blood 115, 3109–3117 (2010).

    Article  Google Scholar 

  15. Ghoreschi, K. et al. J. Immunol. 186, 4234–4243 (2011).

    Article  CAS  Google Scholar 

  16. Andersson, A.K. et al. Arthritis Rheum. 63, 2617–2629 (2011).

    Article  CAS  Google Scholar 

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Correspondence to Thomas S Kupper.

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Divito, S., Kupper, T. Inhibiting Janus kinases to treat alopecia areata. Nat Med 20, 989–990 (2014).

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