Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.
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TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation
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Araujo, E., de Souza, C. & Velloso, L. Atypical transforming growth factor–β signaling in the hypothalamus is linked to diabetes. Nat Med 20, 985–987 (2014). https://doi.org/10.1038/nm.3673
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DOI: https://doi.org/10.1038/nm.3673
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