Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A local circadian clock calls time on lung inflammation

Inflammatory diseases typically display circadian variation in symptom severity. A new study in mice shows how a pulmonary epithelial cell clock controls neutrophil recruitment to the lungs and provides insight into interactions between local and systemic circadian clocks.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The pulmonary clock and inflammatory responses.

Debbie Maizels/Nature Publishing Group


  1. Brusselle, G.G. et al. Lancet 378, 1015–1026 (2011).

    CAS  Article  Google Scholar 

  2. Barnes, P.J. Am. J. Med. 79, 5–9 (1985).

    CAS  Article  Google Scholar 

  3. Calverley, P.M. et al. Thorax 58, 855–860 (2003).

    CAS  Article  Google Scholar 

  4. Hastings, M.H. et al. Nat. Rev. Neurosci. 4, 649–661 (2003).

    CAS  Article  Google Scholar 

  5. Lee, J.H. & Sancar, A. Proc. Natl. Acad. Sci. USA 108, 12036–12041 (2011).

    CAS  Article  Google Scholar 

  6. Keller, M. et al. Proc. Natl. Acad. Sci. USA 106, 21407–21412 (2009).

    CAS  Article  Google Scholar 

  7. Gibbs, J.E. et al. Proc. Natl. Acad. Sci. USA 109, 582–587 (2012).

    CAS  Article  Google Scholar 

  8. Nguyen, K.D. et al. Science 341, 1483–1488 (2013).

    CAS  Article  Google Scholar 

  9. Bellet, M.M. et al. Proc. Natl. Acad. Sci. USA 110, 9897–9902 (2013).

    CAS  Article  Google Scholar 

  10. Gibbs, J. et al. Nat. Med. 20, 919–926 (2014).

    CAS  Article  Google Scholar 

  11. Park, H.Y. et al. Am. J. Respir. Crit. Care Med. 188, 1413–1419 (2013).

    CAS  Article  Google Scholar 

  12. Hwang, J.W. et al. FASEB J. 28, 176–194 (2014).

    CAS  Article  Google Scholar 

  13. Rousselle, A. et al. J. Clin. Invest. 123, 1343–1347 (2013).

    CAS  Article  Google Scholar 

  14. Wright, H.L. et al. Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.80 (10 June 2014).

    Article  Google Scholar 

  15. Mackay, T.W. et al. Thorax 49, 257–262 (1994).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Moira K B Whyte.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Thompson, A., Walmsley, S. & Whyte, M. A local circadian clock calls time on lung inflammation. Nat Med 20, 809–811 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing