Age-related cognitive decline occurs in many mammals, including humans, resulting from a decline in hippocampal function, and it is associated with reduced synaptic plasticity in hippocampal circuits. In this issue of Nature Medicine, a new study shows that cognitive impairment observed in aged mice is largely reversible following exposure to the blood of young mice.
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Paul, S., Reddy, K. Young blood rejuvenates old brains. Nat Med 20, 582–583 (2014). https://doi.org/10.1038/nm.3597
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DOI: https://doi.org/10.1038/nm.3597
