Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment

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Figure 1: Repurposing metformin.

Kim Caesar/Nature Publishing Group

References

  1. 1

    Owen, M.R., Doran, E. & Halestrap, A.P. Biochem. J. 348, 607–614 (2000).

    CAS  Article  Google Scholar 

  2. 2

    Shaw, R.J. et al. Science 310, 1642–1646 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Foretz, M. et al. J. Clin. Invest. 120, 2355–2369 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Franciosi, M. et al. PLoS ONE 8, e71583 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Suissa, S. & Azoulay, L. Diabetes Care 35, 2665–2673 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Pollak, M. Nat. Rev. Cancer 12, 159–169 (2012).

    CAS  Article  Google Scholar 

  7. 7

    Pollak, M. J. Clin. Invest. 123, 3693–3700 (2013).

    CAS  Article  Google Scholar 

  8. 8

    Wallace, D.C. Nat. Rev. Cancer 12, 685–698 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Zakikhani, M., Dowling, R., Fantus, I.G., Sonenberg, N. & Pollak, M. Cancer Res. 66, 10269–10273 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Larsson, O. et al. Proc. Natl. Acad. Sci. USA 109, 8977–8982 (2012).

    CAS  Article  Google Scholar 

  11. 11

    Algire, C. et al. Oncogene 30, 1174–1182 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Shackelford, D.B. et al. Cancer Cell 23, 143–158 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Birsoy, K. et al. Nature 508, 108–112 (2014).

    CAS  Article  Google Scholar 

  14. 14

    Pollak, M. Cancer Cell 23, 263–264 (2013).

    CAS  Article  Google Scholar 

  15. 15

    Gontier, E. et al. Eur. J. Nucl. Med. Mol. Imaging 35, 95–99 (2008).

    CAS  Article  Google Scholar 

  16. 16

    Madiraju, A.K. et al. Nature published online, doi:10.1038/nature13270 (21 May 2014).

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Correspondence to Michael Pollak.

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Pollak, M. Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment. Nat Med 20, 591–593 (2014). https://doi.org/10.1038/nm.3596

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