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An alternative DNA damage pathway to apoptosis in hematological cancers

Nature Medicine volume 20, pages 587–588 (2014)Cite this article

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Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage–induced cell death are largely unknown. A current study has revealed that the Hippo signaling pathway transcriptional regulator YAP1 activates an ABL1/p73-mediated proapoptotic effect in response to DNA damage, suggesting that YAP1 has a tumor suppressor function and that the Hippo pathway is a potential therapeutic target in human cancers.

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Figure 1: YAP1 alternative pathway to apoptosis in hematological cancers.

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Authors and Affiliations

  1. John M. Luk is at China R&D and Scientific Affairs, Janssen, Shanghai, China.,

    John M Luk

  2. Kun-Liang Guan is at the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, California, USA.,

    Kun-Liang Guan

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  1. John M Luk
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  2. Kun-Liang Guan
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Correspondence to John M Luk or Kun-Liang Guan.

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The authors declare no competing financial interests.

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Luk, J., Guan, KL. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med 20, 587–588 (2014). https://doi.org/10.1038/nm.3593

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