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Neonates, antibiotics and the microbiome

As babies leave their mothers' wombs, they are colonized by commensal bacteria. A new study shows that these microbes in a newborn's gut can promote an increase in circulating neutrophils that can guard the body from infections. Altering a neonate's gut microbiota with perinatal antibiotic treatment can impair neutrophils, leaving the newborn vulnerable to attack by harmful bacteria (pages 524–530).

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Figure 1: The neonatal microbiota can increase the amounts of circulating neutrophils to protect the host from potential bacterial infections.

Kim Caesar/Nature Publishing Group


  1. Qazi, S.A. & Stoll, B.J. Pediatr. Infect. Dis. J. 28, S1–S2 (2009).

    Article  Google Scholar 

  2. Kuppala, V.S., Meinzen-Derr, J., Morrow, A.L. & Schibler, K.R. J. Pediatr. 159, 720–725 (2011).

    Article  CAS  Google Scholar 

  3. Sleator, R.D. Med. Hypotheses 74, 214–215 (2010).

    Article  Google Scholar 

  4. Cerf-Bensussan, N. & Gaboriau-Routhiau, V. Nat. Rev. Immunol. 10, 735–744 (2010).

    Article  CAS  Google Scholar 

  5. Deshmukh, H.S. et al. Nat. Med. 20, 524–530 (2014).

    Article  CAS  Google Scholar 

  6. Mantovani, A., Cassatella, M.A., Costantini, C. & Jaillon, S. Nat. Rev. Immunol. 11, 519–531 (2011).

    Article  CAS  Google Scholar 

  7. Jost, T., Lacroix, C., Braegger, C.P. & Chassard, C. PLoS ONE 7, e44595 (2012).

    Article  CAS  Google Scholar 

  8. Coccia, M. et al. J. Exp. Med. 209, 1595–1609 (2012).

    Article  CAS  Google Scholar 

  9. Clarke, T.B. et al. Nat. Med. 16, 228–231 (2010).

    Article  CAS  Google Scholar 

  10. Russell, S.L. et al. EMBO Rep. 13, 440–447 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Paul Kubes.

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Thanabalasuriar, A., Kubes, P. Neonates, antibiotics and the microbiome. Nat Med 20, 469–470 (2014).

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