Hypoferremia of infection: a double-edged sword?

Pharmacologic modulation of iron metabolism may be a potential strategy to control infection caused by the intracellular bacteria Salmonella enterica var. Typhimurium (S. typhimurium) (pages 419–424). The molecular mechanism involves the estrogen-related receptor γ (ERRγ) in the liver, which can be targeted with an inverse agonist to improve survival of infected animals.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: ERRγ-mediated induction of hepcidin increases intracellular iron levels after infection with intracellular pathogens, subsequently enhancing the host's susceptibility to bacterial growth.

References

  1. 1

    Cassat, J.E. & Skaar, E.P. Cell Host Microbe 13, 509–519 (2013).

  2. 2

    Nemeth, E. et al. Blood 101, 2461–2463 (2003).

  3. 3

    Nemeth, E. et al. Science 306, 2090–2093 (2004).

  4. 4

    Knutson, M.D., Oukka, M., Koss, L.M., Aydemir, F. & Wessling-Resnick, M. Proc. Natl. Acad. Sci. USA 102, 1324–1328 (2005).

  5. 5

    Cartwright, G.E., Lauritsen, M.A., Jones, P.J., Merrill, I.M. & Wintrobe, M.M. J. Clin. Invest. 25, 65–80 (1946).

  6. 6

    Bäumler, A.J. & Heffron, F. in Virulence Mechanisms of Bacterial Pathogens (eds. Roth, J.A., Bolin, C.A., Brogden, K.A., Minion, F.C. & Wannemuehler, M.J.) 115–131 (ASM, Washington, DC, 1995).

  7. 7

    Kim, D.K. et al. Nat. Med. 20, 419–424 (2014).

  8. 8

    Kim, D.K. et al. J. Biol. Chem. 287, 21628–21639 (2012).

  9. 9

    Chlosta, S. et al. Infect. Immun. 74, 3065–3067 (2006).

  10. 10

    Nairz, M. et al. Cell. Microbiol. 9, 2126–2140 (2007).

  11. 11

    Mair, S.M. et al. J. Infect. Dis. 204, 685–694 (2011).

  12. 12

    Nairz, M. et al. Eur. J. Immunol. 38, 1923–1936 (2008).

  13. 13

    Nairz, M. et al. J. Exp. Med. 210, 855–873 (2013).

  14. 14

    Eisele, N.A. et al. Cell Host Microbe 14, 171–182 (2013).

  15. 15

    Abdullah, Z. et al. PLoS ONE 7, e37349 (2012).

  16. 16

    Xavier, M.N. et al. Cell Host Microbe 14, 159–170 (2013).

  17. 17

    Kingsley, R.A. et al. Genome Res. 19, 2279–2287 (2009).

  18. 18

    Okoro, C.K. et al. Nat. Genet. 44, 1215–1221 (2012).

Download references

Author information

Correspondence to Andreas J Bäumler.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lokken, K., Tsolis, R. & Bäumler, A. Hypoferremia of infection: a double-edged sword?. Nat Med 20, 335–337 (2014) doi:10.1038/nm.3526

Download citation

Further reading