Bariatric surgery reduces the weight of morbidly obese individuals and exerts beneficial effects on associated metabolic disorders such as type 2 diabetes. However, despite growing traction in this area of metabolic research, questions remain as to the mechanisms that lead to these benefits. New findings propose that the bile acid–activated nuclear receptor FXR mediates the metabolic improvement seen after one particular bariatric surgery approach and that this may involve alterations in the microbiome.
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References
Yanovski, S.Z. & Yanovski, J.A. J. Am. Med. Assoc. 311, 74–86 (2014).
Schauer, P.R. et al. N. Engl. J. Med. 366, 1567–1576 (2012).
Karamanakos, S.N. et al. Ann. Surg. 247, 401–407 (2008).
Ryan, K.K. et al. Nature, doi:10.1038/nature13135 (26 March 2014).
Lefebvre, P. et al. Physiol. Rev. 89, 147–191 (2009).
Ridlon, J.M. et al. J. Lipid Res. 47, 241–259 (2006).
Patti, M.E. et al. Obesity (Silver Spring) 17, 1671–1677 (2009).
Kohli, R. et al. J. Clin. Endocrinol. Metab. 98, E708–E712 (2013).
Sinal, C.J. et al. Cell 102, 731–744 (2000).
Kok, T. et al. J. Biol. Chem. 278, 41930–41937 (2003).
Cariou, B. et al. J. Biol. Chem. 281, 11039–11049 (2006).
Zhang, Y. et al. Mol. Endocrinol. 26, 272–280 (2012).
Prawitt, J. et al. Diabetes 60, 1861–1871 (2011).
Cariou, B. et al. FEBS Lett. 581, 5191–5198 (2007).
Dewulf, E.M. et al. Gut 62, 1112–1121 (2013).
Li, F. et al. Nat. Commun. 4, 2384 (2013).
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Kuipers, F., Groen, A. FXR: the key to benefits in bariatric surgery?. Nat Med 20, 337–338 (2014). https://doi.org/10.1038/nm.3525
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DOI: https://doi.org/10.1038/nm.3525
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