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Targeting a new regulator of erythropoiesis to alleviate anemia

Anemia is a debilitating condition that can be complicated by ineffective erythropoiesis. Two new studies identify GDF11 as a regulator of erythropoiesis and show that its inhibition in mouse models of anemia with ineffective erythropoiesis restores normal erythropoietic differentiation and alleviates anemia (pages 398–407 and 408–414).

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Figure 1: Relieving ineffective hematopoiesis with TGF-β ligand traps.

Katie Vicari


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Correspondence to Robert F Paulson.

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Paulson, R. Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med 20, 334–335 (2014).

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