Targeting a new regulator of erythropoiesis to alleviate anemia

Anemia is a debilitating condition that can be complicated by ineffective erythropoiesis. Two new studies identify GDF11 as a regulator of erythropoiesis and show that its inhibition in mouse models of anemia with ineffective erythropoiesis restores normal erythropoietic differentiation and alleviates anemia (pages 398–407 and 408–414).

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Figure 1: Relieving ineffective hematopoiesis with TGF-β ligand traps.

Katie Vicari

References

  1. 1

    Shander, A., Javidroozi, M., Ozawa, S. & Hare, G.M. Br. J. Anaesth. 107 (suppl. 1), i41–i59 (2011).

  2. 2

    Dicato, M. & Plawny, L. Curr. Opin. Oncol. 22, 307–311 (2010).

  3. 3

    Dussiot, M. et al. Nat. Med. 20, 398–407 (2014).

  4. 4

    Suragani, R.N.V.S. et al. Nat. Med. 20, 408–414 (2014).

  5. 5

    Paulson, R.F., Shi, L. & Wu, D.C. Curr. Opin. Hematol. 18, 139–145 (2011).

  6. 6

    Ginzburg, Y. & Rivella, S. Blood 118, 4321–4330 (2011).

  7. 7

    Rivella, S. Blood Rev. 26 Suppl 1, S12–S15 (2012).

  8. 8

    Tanno, T. & Miller, J.L. Adv. Hematol. 2010, 358283 (2010).

  9. 9

    Gardenghi, S. et al. J. Clin. Invest. 120, 4466–4477 (2010).

  10. 10

    Li, H. et al. Nat. Med. 16, 177–182 (2010).

  11. 11

    Libani, I.V. et al. Blood 112, 875–885 (2008).

  12. 12

    Ruckle, J. et al. J. Bone Miner. Res. 24, 744–752 (2009).

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Correspondence to Robert F Paulson.

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Paulson, R. Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med 20, 334–335 (2014) doi:10.1038/nm.3524

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