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Targeting a new regulator of erythropoiesis to alleviate anemia

Nature Medicine volume 20, pages 334–335 (2014)Cite this article

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Anemia is a debilitating condition that can be complicated by ineffective erythropoiesis. Two new studies identify GDF11 as a regulator of erythropoiesis and show that its inhibition in mouse models of anemia with ineffective erythropoiesis restores normal erythropoietic differentiation and alleviates anemia (pages 398–407 and 408–414).

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Figure 1: Relieving ineffective hematopoiesis with TGF-β ligand traps.

Katie Vicari

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  1. Department of Veterinary and Biomedical Sciences, Robert F. Paulson is at the Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pennsylvania, USA.,

    Robert F Paulson

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  1. Robert F Paulson
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Correspondence to Robert F Paulson.

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Paulson, R. Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med 20, 334–335 (2014). https://doi.org/10.1038/nm.3524

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