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Tumor Heterogeneity Confounds and Illuminates: A case for Darwinian tumor evolution

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Figure 1: The role of ESR1 mutations in breast cancer endocrine resistance.

Katie Vicari

References

  1. Swaby, R.F., Sharma, C.G. & Jordan, V.C. Rev. Endocr. Metab. Disord. 8, 229–239 (2007).

    CAS  Article  Google Scholar 

  2. Musgrove, E.A. & Sutherland, R.L. Nat. Rev. Cancer 9, 631–643 (2009).

    CAS  Article  Google Scholar 

  3. Karnik, P.S., Kulkarni, S., Liu, X.P., Budd, G.T. & Bukowski, R.M. Cancer Res. 54, 349–353 (1994).

    CAS  PubMed  Google Scholar 

  4. Roodi, N. et al. J. Natl. Cancer Inst. 87, 446–451 (1995).

    CAS  Article  Google Scholar 

  5. Zhang, Q.X., Borg, A., Wolf, D.M., Oesterreich, S. & Fuqua, S.A. Cancer Res. 57, 1244–1249 (1997).

    CAS  PubMed  Google Scholar 

  6. TCGA. Nature 490, 61–70 (2012).

  7. Li, S. et al. Cell Reports 4, 1116–1130 (2013).

    CAS  Article  Google Scholar 

  8. Toy, W. et al. Nat. Genet. 45, 1439–1445 (2013).

    CAS  Article  Google Scholar 

  9. Robinson, D.R. et al. Nat. Genet. 45, 1446–1451 (2013).

    CAS  Article  Google Scholar 

  10. Jeselsohn, R. et al. Clin. Cancer Res. doi:10.1158/1078-0432.CCR-13-2332 (7 January 2014).

  11. Merenbakh-Lamin, K. et al. Cancer Res. 73, 6856–6864 (2013).

    CAS  Article  Google Scholar 

  12. Baselga, J. et al. N. Engl. J. Med. 366, 520–529 (2012).

    CAS  Article  Google Scholar 

  13. Di Leo, A. et al. J. Natl. Cancer Inst. 106, djt337 (2014).

    Article  Google Scholar 

  14. Osborne, C.K. & Schiff, R. Annu. Rev. Med. 62, 233–247 (2011).

    CAS  Article  Google Scholar 

  15. Greaves, M. & Maley, C.C. Nature 481, 306–313 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Kornelia Polyak.

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Polyak, K. Tumor Heterogeneity Confounds and Illuminates: A case for Darwinian tumor evolution. Nat Med 20, 344–346 (2014). https://doi.org/10.1038/nm.3518

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