Tumor Heterogeneity Confounds and Illuminates: A case for Darwinian tumor evolution

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The role of ESR1 mutations in breast cancer endocrine resistance.

Katie Vicari

References

  1. 1

    Swaby, R.F., Sharma, C.G. & Jordan, V.C. Rev. Endocr. Metab. Disord. 8, 229–239 (2007).

  2. 2

    Musgrove, E.A. & Sutherland, R.L. Nat. Rev. Cancer 9, 631–643 (2009).

  3. 3

    Karnik, P.S., Kulkarni, S., Liu, X.P., Budd, G.T. & Bukowski, R.M. Cancer Res. 54, 349–353 (1994).

  4. 4

    Roodi, N. et al. J. Natl. Cancer Inst. 87, 446–451 (1995).

  5. 5

    Zhang, Q.X., Borg, A., Wolf, D.M., Oesterreich, S. & Fuqua, S.A. Cancer Res. 57, 1244–1249 (1997).

  6. 6

    TCGA. Nature 490, 61–70 (2012).

  7. 7

    Li, S. et al. Cell Reports 4, 1116–1130 (2013).

  8. 8

    Toy, W. et al. Nat. Genet. 45, 1439–1445 (2013).

  9. 9

    Robinson, D.R. et al. Nat. Genet. 45, 1446–1451 (2013).

  10. 10

    Jeselsohn, R. et al. Clin. Cancer Res. doi:10.1158/1078-0432.CCR-13-2332 (7 January 2014).

  11. 11

    Merenbakh-Lamin, K. et al. Cancer Res. 73, 6856–6864 (2013).

  12. 12

    Baselga, J. et al. N. Engl. J. Med. 366, 520–529 (2012).

  13. 13

    Di Leo, A. et al. J. Natl. Cancer Inst. 106, djt337 (2014).

  14. 14

    Osborne, C.K. & Schiff, R. Annu. Rev. Med. 62, 233–247 (2011).

  15. 15

    Greaves, M. & Maley, C.C. Nature 481, 306–313 (2012).

Download references

Author information

Correspondence to Kornelia Polyak.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Polyak, K. Tumor Heterogeneity Confounds and Illuminates: A case for Darwinian tumor evolution. Nat Med 20, 344–346 (2014) doi:10.1038/nm.3518

Download citation

Further reading