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Rejuvenating aged muscle stem cells

Decreased muscle stem cell function in aging has long been shown to depend on altered environmental cues, whereas the contribution of intrinsic mechanisms remained less clear. Two new studies now reveal that cell-autonomous changes in the p38 mitogen-activated protein kinase pathway are major phenotype determinants of aged muscles stem cells (pages 255271).

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Figure 1: Increased p38 signaling impairs self-renewal of aged satellite cells.

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Correspondence to Michael A Rudnicki.

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Bentzinger, C., Rudnicki, M. Rejuvenating aged muscle stem cells. Nat Med 20, 234–235 (2014). https://doi.org/10.1038/nm.3499

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