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Harnessing Microbiota to Kill a Pathogen: The sweet tooth of Clostridium difficile

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Figure 1: Sialic acid consumption in C. difficile infection after antibiotic treatment.

Marina Corral Spence


  1. Cohen, S.H. et al. Infect. Control Hosp. Epidemiol. 31, 431–455 (2010).

    Article  Google Scholar 

  2. Karadsheh, Z. & Sule, S. N. Am. J. Med. Sci. 5, 339–343 (2013).

    Article  Google Scholar 

  3. Human Microbiome Project Consortium. Nature 486, 207–214 (2012).

  4. Dethlefsen, L., Huse, S., Sogin, M. & Relman, D. PLoS Biol. 6, e280 (2008).

    Article  Google Scholar 

  5. van Nood, E. et al. N. Engl. J. Med. 368, 407–415 (2013).

    CAS  Article  Google Scholar 

  6. Borody, T.J. & Khoruts, A. Nat. Rev. Gastroenterol. Hepatol. 9, 88–96 (2012).

    CAS  Article  Google Scholar 

  7. Ng, K.M. et al. Nature 502, 96–99 (2013).

    CAS  Article  Google Scholar 

  8. McFarland, L.V. et al. J. Am. Med. Assoc. 271, 1913–1918 (1994).

    CAS  Article  Google Scholar 

  9. Lozupone, C.A. et al. Proc. Natl. Acad. Sci. USA 105, 15076–15081 (2008).

    CAS  Article  Google Scholar 

  10. Hwang, I.Y., et al. ACS Synth. Biol. doi:10.1021/sb400077j (10 September 2013).

  11. Yoo, J.W., Irvine, D.J., Discher, D.E. & Mitragotri, S. Nat. Rev. Drug Discov. 10, 521–535 (2011).

    CAS  Article  Google Scholar 

  12. Duan, F. & March, J.C. Proc. Natl. Acad. Sci. USA 107, 11260–11264 (2010).

    CAS  Article  Google Scholar 

  13. Tvede, M. & Rask-Madsen, J. Lancet 1, 1156–1160 (1989).

    CAS  Article  Google Scholar 

  14. Lawley, T.D. et al. PLoS Pathog. 8, e1002995 (2012).

    CAS  Article  Google Scholar 

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Correspondence to Ruth E Ley.

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Ley, R. Harnessing Microbiota to Kill a Pathogen: The sweet tooth of Clostridium difficile. Nat Med 20, 248–249 (2014).

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