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A Fox of a different color: FoxA1 programs a new regulatory T cell subset

Nature Medicine volume 20, pages 236237 (2014) | Download Citation

Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), but its mechanism of protection remains obscure. A new study shows that IFN-β induces FoxA1+ regulatory T cells, a new regulatory T cell population, which suppress conventional T cells via programmed cell death 1 ligand 1. This cell subset limits disease in a mouse model of MS and was found in patients with MS who responded to IFN-β therapy (pages 272–282).

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Affiliations

  1. Greg M. Delgoffe and Dario A.A. Vignali are at the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

    • Greg M Delgoffe
    •  & Dario A A Vignali

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Dario A A Vignali.

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DOI

https://doi.org/10.1038/nm.3493

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