Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Increase in dietary fiber dampens allergic responses in the lung

A new study in mice provides a link between dietary fiber intake, amounts of intestinal and systemic short-chain fatty acids, changes in the microbiome and allergic responses in the airways. The findings support the growing appreciation of a potential therapeutic role of diet in treating allergic diseases (pages 159–166).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Different amounts of dietary fiber intake can change allergic airway responses and modify susceptibility to inflammatory disease.

Marina Corral Spence


  1. Devereux, G. Nat. Rev. Immunol. 6, 869–874 (2006).

    Article  CAS  Google Scholar 

  2. Noverr, M.C. & Huffnagle, G.B. Clin. Exp. Allergy 35, 1511–1520 (2005).

    Article  CAS  Google Scholar 

  3. Louis, P. et al. J. Bacteriol. 186, 2099–2106 (2004).

    Article  CAS  Google Scholar 

  4. Sanderson, I.R. J. Nutr. 137, 2557S–2562S (2007).

    Article  CAS  Google Scholar 

  5. Atarashi, K. et al. Science 331, 337–341 (2011).

    Article  CAS  Google Scholar 

  6. Trompette, A. et al. Nat. Med. 20, 159–166 (2014).

    Article  CAS  Google Scholar 

  7. Ulven, T. Front. Endocrinol. (Lausanne) 3, 111 (2012).

    Article  Google Scholar 

  8. Denburg, J.A., Inman, M.D., Leber, B., Sehmi, R. & O'Byrne, P.M. Allergy 51, 141–148 (1996).

    Article  CAS  Google Scholar 

  9. Sehmi, R. et al. Am. J. Respir. Cell Mol. Biol. 15, 645–655 (1996).

    Article  CAS  Google Scholar 

  10. Lambrecht, B.N., Carro-Muino, I., Vermaelen, K. & Pauwels, R.A. Am. J. Respir. Cell Mol. Biol. 20, 1165–1174 (1999).

    Article  CAS  Google Scholar 

  11. Wang, Z. et al. Nature 472, 57–63 (2011).

    Article  CAS  Google Scholar 

  12. Noverr, M.C., Falkowski, N.R., McDonald, R.A., McKenzie, A.N. & Huffnagle, G.B. Infect. Immun. 73, 30–38 (2005).

    Article  CAS  Google Scholar 

  13. Noverr, M.C., Noggle, R.M., Toews, G.B. & Huffnagle, G.B. Infect. Immun. 72, 4996–5003 (2004).

    Article  CAS  Google Scholar 

  14. Hill, D.A. et al. Nat. Med. 18, 538–546 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gary B Huffnagle.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huffnagle, G. Increase in dietary fiber dampens allergic responses in the lung. Nat Med 20, 120–121 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing