News & Views | Published:

Increase in dietary fiber dampens allergic responses in the lung

Nature Medicine volume 20, pages 120121 (2014) | Download Citation

A new study in mice provides a link between dietary fiber intake, amounts of intestinal and systemic short-chain fatty acids, changes in the microbiome and allergic responses in the airways. The findings support the growing appreciation of a potential therapeutic role of diet in treating allergic diseases (pages 159–166).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Nat. Rev. Immunol. 6, 869–874 (2006).

  2. 2.

    & Clin. Exp. Allergy 35, 1511–1520 (2005).

  3. 3.

    et al. J. Bacteriol. 186, 2099–2106 (2004).

  4. 4.

    J. Nutr. 137, 2557S–2562S (2007).

  5. 5.

    et al. Science 331, 337–341 (2011).

  6. 6.

    et al. Nat. Med. 20, 159–166 (2014).

  7. 7.

    Front. Endocrinol. (Lausanne) 3, 111 (2012).

  8. 8.

    , , , & Allergy 51, 141–148 (1996).

  9. 9.

    et al. Am. J. Respir. Cell Mol. Biol. 15, 645–655 (1996).

  10. 10.

    , , & Am. J. Respir. Cell Mol. Biol. 20, 1165–1174 (1999).

  11. 11.

    et al. Nature 472, 57–63 (2011).

  12. 12.

    , , , & Infect. Immun. 73, 30–38 (2005).

  13. 13.

    , , & Infect. Immun. 72, 4996–5003 (2004).

  14. 14.

    et al. Nat. Med. 18, 538–546 (2012).

Download references

Author information

Affiliations

  1. Gary B. Huffnagle is at the Department of Internal Medicine–Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.

    • Gary B Huffnagle

Authors

  1. Search for Gary B Huffnagle in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Gary B Huffnagle.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm.3472

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing