A new study in mice provides a link between dietary fiber intake, amounts of intestinal and systemic short-chain fatty acids, changes in the microbiome and allergic responses in the airways. The findings support the growing appreciation of a potential therapeutic role of diet in treating allergic diseases (pages 159–166).
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Devereux, G. Nat. Rev. Immunol. 6, 869–874 (2006).
Noverr, M.C. & Huffnagle, G.B. Clin. Exp. Allergy 35, 1511–1520 (2005).
Louis, P. et al. J. Bacteriol. 186, 2099–2106 (2004).
Sanderson, I.R. J. Nutr. 137, 2557S–2562S (2007).
Atarashi, K. et al. Science 331, 337–341 (2011).
Trompette, A. et al. Nat. Med. 20, 159–166 (2014).
Ulven, T. Front. Endocrinol. (Lausanne) 3, 111 (2012).
Denburg, J.A., Inman, M.D., Leber, B., Sehmi, R. & O'Byrne, P.M. Allergy 51, 141–148 (1996).
Sehmi, R. et al. Am. J. Respir. Cell Mol. Biol. 15, 645–655 (1996).
Lambrecht, B.N., Carro-Muino, I., Vermaelen, K. & Pauwels, R.A. Am. J. Respir. Cell Mol. Biol. 20, 1165–1174 (1999).
Wang, Z. et al. Nature 472, 57–63 (2011).
Noverr, M.C., Falkowski, N.R., McDonald, R.A., McKenzie, A.N. & Huffnagle, G.B. Infect. Immun. 73, 30–38 (2005).
Noverr, M.C., Noggle, R.M., Toews, G.B. & Huffnagle, G.B. Infect. Immun. 72, 4996–5003 (2004).
Hill, D.A. et al. Nat. Med. 18, 538–546 (2012).
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Huffnagle, G. Increase in dietary fiber dampens allergic responses in the lung. Nat Med 20, 120–121 (2014). https://doi.org/10.1038/nm.3472
This article is cited by
An Overview of Integrative Therapies in Asthma Treatment
Current Allergy and Asthma Reports (2014)