Drug-resistant tuberculosis: a new shot on goal

Modification of a natural product with antibiotic properties to block its efflux from Mycobacterium tuberculosis results in a new drug candidate for tuberculosis with a promising therapeutic profile in mice (pages 152–158).

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Figure 1: Mtb is susceptible to semisynthetic spectinamides but not to spectinomycin, the natural product from which spectinamides are derived.

Marina Corral Spence

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Correspondence to Carl Nathan.

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Nathan, C. Drug-resistant tuberculosis: a new shot on goal. Nat Med 20, 121–123 (2014). https://doi.org/10.1038/nm.3470

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