Evans, W.J. & Campbell, W.W. Sarcopenia and age-related changes in body composition and functional capacity. J. Nutr. 123, 465–468 (1993).
Baumgartner, R.N. et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 147, 755–763 (1998).
Roubenoff, R. Sarcopenia: a major modifiable cause of frailty in the elderly: Sarcopenia in aging. J. Nutr. Health Aging 4, 140–142 (2000).
Landi, F. et al. Sarcopenia and mortality risk in frail older persons aged 80 years and older: results from ilSIRENTE study. Age Ageing 42, 203–209 (2013).
Janssen, I., Shepard, D.S., Katzmarzyk, P.T. & Roubenoff, R. The healthcare costs of sarcopenia in the United States. J. Am. Geriatr. Soc. 52, 80–85 (2004).
Brooks, S.V. & Faulkner, J.A. Contraction-induced injury: recovery of skeletal muscles in young and old mice. Am. J. Physiol. 258, C436–C442 (1990).
Grounds, M.D. Age-associated changes in the response of skeletal muscle cells to exercise and regeneration. Ann. NY Acad. Sci. 854, 78–91 (1998).
Karakelides, H. & Nair, K.S. Sarcopenia of aging and its metabolic impact. Curr. Top. Dev. Biol. 68, 123–148 (2005).
Day, K., Shefer, G., Shearer, A. & Yablonka-Reuveni, Z. The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny. Dev. Biol. 340, 330–343 (2010).
Mauro, A. Satellite cell of skeletal muscle fibers. J. Biophys. Biochem. Cytol. 9, 493–495 (1961).
Sambasivan, R. et al. Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development 138, 3647–3656 (2011).
Lepper, C., Partridge, T.A. & Fan, C.M. An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development 138, 3639–3646 (2011).
Murphy, M.M., Lawson, J.A., Mathew, S.J., Hutcheson, D.A. & Kardon, G. Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development 138, 3625–3637 (2011).
Sadeh, M. Effects of aging on skeletal muscle regeneration. J. Neurol. Sci. 87, 67–74 (1988).
McGeachie, J.K. & Grounds, M. Retarded myogenic cell replication in regenerating skeletal muscles of old mice: an autoradiographic study in young and old BALBc and SJL/J mice. Cell Tissue Res. 280, 277–282 (1995).
Marsh, D.R., Criswell, D.S., Carson, J.A. & Booth, F.W. Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats. J. Appl. Physiol. 83, 1270–1275 (1997).
Conboy, I.M., Conboy, M.J., Smythe, G.M. & Rando, T.A. Notch-mediated restoration of regenerative potential to aged muscle. Science 302, 1575–1577 (2003).
Collins, C.A., Zammit, P.S., Ruiz, A.P., Morgan, J.E. & Partridge, T.A. A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells 25, 885–894 (2007).
Carlson, B.M. & Faulkner, J.A. Muscle transplantation between young and old rats: age of host determines recovery. Am. J. Physiol. 256, C1262–C1266 (1989).
Carlson, B.M. & Faulkner, J.A. The Regeneration of Noninnervated Musele Grafts and Marcaine-Treated Muscles in Young and Old Rats. J. Gerontol. A Biol. Sci. Med. Sci. 51, B43–B49 (1996).
Conboy, I.M. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760–764 (2005).
Brack, A.S. & Rando, T.A. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 3, 226–237 (2007).
Hall, J.K., Banks, G.B., Chamberlain, J.S. & Olwin, B.B. Prevention of muscle aging by myofiber-associated satellite cell transplantation. Sci. Transl. Med. 2, 57ra83 (2010).
Hannon, K., Kudla, A.J., McAvoy, M.J., Clase, K.L. & Olwin, B.B. Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. J. Cell Biol. 132, 1151–1159 (1996).
Sheehan, S.M. & Allen, R.E. Skeletal muscle satellite cell proliferation in response to members of the fibroblast growth factor family and hepatocyte growth factor. J. Cell. Physiol. 181, 499–506 (1999).
Kudla, A.J. et al. The FGF receptor-1 tyrosine kinase domain regulates myogenesis but is not sufficient to stimulate proliferation. J. Cell Biol. 142, 241–250 (1998).
Flanagan-Steet, H., Hannon, K., McAvoy, M.J., Hullinger, R. & Olwin, B.B. Loss of FGF receptor 1 signaling reduces skeletal muscle mass and disrupts myofiber organization in the developing limb. Dev. Biol. 218, 21–37 (2000).
Kästner, S., Elias, M.C., Rivera, A.J. & Yablonka-Reuveni, Z. Gene expression patterns of the fibroblast growth factors and their receptors during myogenesis of rat satellite cells. J. Histochem. Cytochem. 48, 1079–1096 (2000).
Lagha, M. et al. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 22, 1828–1837 (2008).
Jones, N.C., Fedorov, Y.V., Rosenthal, R.S. & Olwin, B.B. ERK1/2 is required for myoblast proliferation but is dispensable for muscle gene expression and cell fusion. J. Cell. Physiol. 186, 104–115 (2001).
Jones, N.C. et al. The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell. J. Cell Biol. 169, 105–116 (2005).
Chakkalakal, J.V., Jones, K.M., Basson, M.A. & Brack, A.S. The aged niche disrupts muscle stem cell quiescence. Nature 490, 355–360 (2012).
Troy, A. et al. Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of p38α/β MAPK. Cell Stem Cell 11, 541–553 (2012).
Kang, J.S. et al. A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation. J. Cell Biol. 182, 497–507 (2008).
Gillespie, M.A. et al. p38-gamma-dependent gene silencing restricts entry into the myogenic differentiation program. J. Cell Biol. 187, 991–1005 (2009).
Shefer, G., Van de Mark, D.P., Richardson, J.B. & Yablonka-Reuveni, Z. Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle. Dev. Biol. 294, 50–66 (2006).
Cornelison, D.D., Filla, M.S., Stanley, H.M., Rapraeger, A.C. & Olwin, B.B. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Dev. Biol. 239, 79–94 (2001).
Whitney, M.L., Otto, K.G., Blau, C.A., Reinecke, H. & Murry, C.E. Control of myoblast proliferation with a synthetic ligand. J. Biol. Chem. 276, 41191–41196 (2001).
Stevens, K.R. et al. Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts. Hum. Gene Ther. 18, 401–412 (2007).
Faulkner, J.A., Larkin, L.M., Claflin, D.R. & Brooks, S.V. Age-related changes in the structure and function of skeletal muscles. Clin. Exp. Pharmacol. Physiol. 34, 1091–1096 (2007).
Rüegg, M.A. & Glass, D.J. Molecular mechanisms and treatment options for muscle wasting diseases. Annu. Rev. Pharmacol. Toxicol. 51, 373–395 (2011).
Brien, P., Pugazhendhi, D., Woodhouse, S., Oxley, D. & Pell, J.M. P38α MAPK regulates adult muscle stem cell fate by restricting progenitor proliferation during postnatal growth and repair. Stem Cells 31, 1597–1610 (2013).
Cornelison, D.D. et al. Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes Dev. 18, 2231–2236 (2004).
Yayon, A., Klagsbrun, M., Esko, J., Leder, P. & Ornitz, D. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64, 841–848 (1991).
Rapraeger, A.C., Krufka, A. & Olwin, B.B. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252, 1705–1708 (1991).
Schlessinger, J. et al. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol. Cell 6, 743–750 (2000).
Huynh, M.B. et al. Age-related changes in rat myocardium involve altered capacities of glycosaminoglycans to potentiate growth factor functions and heparan sulfate-altered sulfation. J. Biol. Chem. 287, 11363–11373 (2012).
Williamson, K.A. et al. Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans. Aging Cell 12, 139–147 (2013).
Welm, B.E. et al. Inducible dimerization of FGFR1 development of a mouse model to analyze progressive transformation of the mammary gland. J. Cell Biol. 157, 703–714 (2002).