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A new unexpected twist in newborn immunity

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  1. Elahi, S. et al. Immunosuppressive CD71 erythroid cells compromise neonatal host defence against infection. Nature 504, 158–162 (2013).

    Article  CAS  Google Scholar 

  2. Adkins, B. Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an “immunodiverse” developmental state. Immunol. Res. 57, 246–257 (2013).

    Article  CAS  Google Scholar 

  3. Levy, O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat. Rev. Immunol. 7, 379–390 (2007).

    Article  CAS  Google Scholar 

  4. Mold, J.E. et al. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science 330, 1695–1699 (2010).

    Article  CAS  Google Scholar 

  5. Pettengill, M. et al. Soluble ecto-5′-nucleotidase (5′NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J. Biol. Chem. 288, 27315–27326 (2013).

    Article  CAS  Google Scholar 

  6. Kollmann, T.R., Levy, O., Montgomery, R.R. & Goriely, S. Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. Immunity 37, 771–783 (2012).

    Article  CAS  Google Scholar 

  7. Levy, O. & Netea, M.G. Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines. Pediatr. Res. doi:10.1038/pr.2013.214 (6 November 2013).

    Article  CAS  Google Scholar 

  8. Matamoros, S. et al. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 21, 167–173 (2013).

    Article  CAS  Google Scholar 

  9. Lathrop, S.K. et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 478, 250–254 (2011).

    Article  CAS  Google Scholar 

  10. Hooper, L.V. et al. Interactions between the microbiota and the immune system. Science 336, 1268–1273 (2012).

    Article  CAS  Google Scholar 

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Competing interests

O.L. has consulted for GlaxoSmithKline and MedImmune regarding development of immunomodulatory agents to prevent early-life infection. The other authors declare no conflict of interest.

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A new unexpected twist in newborn immunity. Nat Med 20, 22–23 (2014).

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