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Good guys gone bad: exTreg cells promote autoimmune arthritis

Nature Medicine volume 20, pages 1517 (2014) | Download Citation

Under most circumstances, Foxp3+ regulatory T (Treg) cells are a stable T cell population essential for maintaining self-tolerance. A study now shows that the inflammatory environment in autoimmune arthritis induces conversion of a subset of Foxp3+ T cells into interleukin-17–producing cells that contribute to disease pathogenesis (pages 62–68).

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Author information

Affiliations

  1. Nicole Joller and Vijay K. Kuchroo are at the Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • Nicole Joller
    •  & Vijay K Kuchroo

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The authors declare no competing financial interests.

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Correspondence to Vijay K Kuchroo.

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DOI

https://doi.org/10.1038/nm.3439

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