Under most circumstances, Foxp3+ regulatory T (Treg) cells are a stable T cell population essential for maintaining self-tolerance. A study now shows that the inflammatory environment in autoimmune arthritis induces conversion of a subset of Foxp3+ T cells into interleukin-17–producing cells that contribute to disease pathogenesis (pages 62–68).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rubtsov, Y.P. et al. Science 329, 1667–1671 (2010).
Fu, W. et al. Nat. Immunol. 13, 972–980 (2012).
Zhou, X. et al. Nat. Immunol. 10, 1000–1007 (2009).
Cvetanovich, G.L. & Hafler, D.A. Curr. Opin. Immunol. 22, 753–760 (2010).
Komatsu, N. et al. Nat. Med. 20, 62–68 (2014).
Bailey-Bucktrout, S.L. et al. Immunity 39, 949–962 (2013).
Edwards, J.R. & Mundy, G.R. Rheumatology 7, 235–243 (2011).
Miyao, T. et al. Immunity 36, 262–275 (2012).
Ohkura, N. et al. Immunity 37, 785–799 (2012).
Williams, L.M. & Rudensky, A.Y. Nat. Immunol. 8, 277–284 (2007).
Koch, M.A. et al. Nat. Immunol. 10, 595–602 (2009).
Chaudhry, A. et al. Science 326, 986–991 (2009).
Bettelli, E. et al. Nature 441, 235–238 (2006).
Korn, T. et al. Proc. Natl. Acad. Sci. USA 105, 18460–18465 (2008).
Nie, H. et al. Nat. Med. 19, 322–328 (2013).
Korn, T. et al. Nat. Med. 13, 423–431 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Joller, N., Kuchroo, V. Good guys gone bad: exTreg cells promote autoimmune arthritis. Nat Med 20, 15–17 (2014). https://doi.org/10.1038/nm.3439
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3439
This article is cited by
-
Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (MS) Patients In Vitro
Inflammation (2019)
-
Paradoxical Expansion of Th1 and Th17 Lymphocytes in Rheumatoid Arthritis Following Infliximab Treatment: a Possible Explanation for a Lack of Clinical Response
Journal of Clinical Immunology (2015)