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An innate link between obesity and asthma

The concordant epidemics of asthma and obesity are both associated with inflammation, and obesity has been shown to be an independent risk factor for asthma. A new study in mice indicates that part of the immunological connection between obesity and asthma involves inflammasome activation and production of the cytokine interleukin-17 by innate lymphoid cells in the lung (pages 54–61).

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Figure 1: A model for the immunological mechanisms involved in obesity-induced AHR.

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Correspondence to Juan C Celedón or Jay K Kolls.

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Celedón, J., Kolls, J. An innate link between obesity and asthma. Nat Med 20, 19–20 (2014). https://doi.org/10.1038/nm.3433

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