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Metabolic Disease Puts Up a Fight: Microbes, metabolism and medications

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Figure 1: Metabolic effects of metformin in the host and gut microbiota.

Katie Vicari


  1. Guarner, F. & Malagelada, J.R. Lancet 361, 512–519 (2003).

    Article  PubMed  Google Scholar 

  2. DiBaise, J.K. et al. Mayo Clin. Proc. 83, 460–469 (2008).

    Article  PubMed  Google Scholar 

  3. Turnbaugh, P.J. et al. Sci. Transl. Med. 1, 6ra14 (2009.).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Faith, J.J. et al. Science 341, 1237439 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Li, M. et al. Proc. Natl. Acad. Sci. USA 105, 2117–2122 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cabreiro, F. et al. Cell 153, 228–239 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Anderson, O.S., Sant, K.E. & Dolinoy, D.C. J. Nutr. Biochem. 23, 853–859 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Shin, N.R. et al. Gut doi:10.1136/gutjnl-2012-303839 (26 June 2013).

  9. Inzucchi, S.E. J. Am. Med. Assoc. 287, 360–372 (2002).

    Article  CAS  Google Scholar 

  10. DeFronzo, R.A. & Goodman, A.M. N. Engl. J. Med. 333, 541–549 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Borody, T.J. & Campbell, J. Gastroenterol. Clin. North Am. 41, 781–803 (2012).

    Article  PubMed  Google Scholar 

  12. Preidis, G.A. & Versalovic, J. Gastroenterology 136, 2015–2031 (2009).

    Article  PubMed  CAS  Google Scholar 

Download references

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Correspondence to Eleftheria Maratos-Flier.

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Maratos-Flier, E. Metabolic Disease Puts Up a Fight: Microbes, metabolism and medications. Nat Med 19, 1218–1219 (2013).

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