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In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release

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Figure 1: The mechanism of neurotransmitter release and recycling.
Figure 2: An initial model of the vesicle fusion complex.
Figure 3: Model of the membrane fusion reaction.
Figure 4: The two possible engagements of SNARE coils suggested different functions.
Figure 5: A later model of the vesicle fusion complex.
Figure 6: Specific sets of SNARE proteins mediate intracellular membrane trafficking in all cells.


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I would like to especially thank the many members of my laboratory group whom I have had the pleasure to work with over the years. I regret that all of your accomplishments could not be mentioned individually. Also, I would like to thank the others in this field who have made many important contributions too numerous to mention in this short Essay.

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Correspondence to Richard H Scheller.

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R.H.S. is employed by Genentech, Inc.

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Scheller, R. In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release. Nat Med 19, 1232–1235 (2013).

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