TACE-mediated proteolysis is a key event interfering with both Alzheimer's and prion diseases. A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies (pages 1124–1131).
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Checler, F. Alzheimer's and prion diseases: PDK1 at the crossroads. Nat Med 19, 1088–1090 (2013). https://doi.org/10.1038/nm.3332
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DOI: https://doi.org/10.1038/nm.3332
