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Roadblocks to translational advances on metastasis research

Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups and committed funding bodies. Despite these efforts, the development of effective drugs to prevent systemic dissemination of cancer cells or to eliminate overt metastasis in secondary organs remains a challenge to both researchers and physicians. In an attempt to tackle the most relevant and timely translational issues, a meeting held in 2012 as a result of a successful partnership between the Volkswagen Foundation and Nature Medicine brought together a group of metastasis research experts to identify the most important hurdles and help create a framework for potential clinical and translational strategies.

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Acknowledgements

T.B. is supported by the Deutsche Forschungsgemeinschaft (SFB850, B2 and SFB992, C06) and the Deutsche Krebshilfe (grant 109430).

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Correspondence to Thomas Brabletz, David Lyden, Patricia S Steeg or Zena Werb.

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P.S.S. receives research funding from Sanofi. The other authors declare no conflict of interest.

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Brabletz, T., Lyden, D., Steeg, P. et al. Roadblocks to translational advances on metastasis research. Nat Med 19, 1104–1109 (2013). https://doi.org/10.1038/nm.3327

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