Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The origin of scar-forming kidney myofibroblasts

Nature Medicine volume 19, pages 964–966 (2013)Cite this article

Subjects

Whereas diabetes and hypertension predominate as the etiology of chronic kidney disease (CKD), all primary causes share a common progression pathway due to scarring or fibrosis. Understanding what cells are the sources of scar-forming cells is of utmost importance (pages 1047–1053).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Origin of scar-associated kidney myofibroblasts.

Marina Corral Spence

References

  1. LeBleu, V. et al. Nat. Med. 19, 1047–1053 (2013).

    Article  CAS  Google Scholar 

  2. Iwano, M. et al. J. Clin. Invest. 110, 341–350 (2002).

    Article  CAS  Google Scholar 

  3. Quaggin, S.E. & Kapus, A. Kidney Int. 80, 41–50 (2011).

    Article  Google Scholar 

  4. Zeisberg, E.M., Potenta, S.E., Sugimoto, H., Zeisberg, M. & Kalluri, R. J. Am. Soc. Nephrol. 19, 2282–2287 (2008).

    Article  Google Scholar 

  5. Lin, S.L., Kisseleva, T., Brenner, D.A. & Duffield, J.S. Am. J. Pathol. 173, 1617–1627 (2008).

    Article  CAS  Google Scholar 

  6. Humphreys, B.D. et al. Am. J. Pathol. 176, 85–97 (2010).

    Article  CAS  Google Scholar 

  7. Asada, N. et al. J. Clin. Invest. 121, 3981–3990 (2011).

    Article  CAS  Google Scholar 

  8. Tang, W.W. et al. Am. J. Pathol. 148, 1169–1180 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Eddy, A.A., Lopez-Guisa, J.M., Okamura, D.M. & Yamaguchi, I. Pediatr. Nephrol. 27, 1233–1247 (2012).

    Article  Google Scholar 

  10. Ludin, A. et al. Nat. Immunol. 13, 1072–1082 (2012).

    Article  CAS  Google Scholar 

  11. Reich, B. et al. Kidney Int. 84, 78–89 (2013).

    Article  CAS  Google Scholar 

  12. Lee, C.H., Shah, B., Moioli, E.K. & Mao, J.J. J. Clin. Invest. 120, 3340–3349 (2010).

    Article  CAS  Google Scholar 

  13. Yang, L. et al. Am. J. Pathol. 181, 85–97 (2012).

    Article  CAS  Google Scholar 

  14. Melchior-Becker, A. et al. J. Biol. Chem. 286, 17365–17375 (2011).

    Article  CAS  Google Scholar 

  15. López-Guisa, J.M. et al. J. Am. Soc. Nephrol. 23, 236–251 (2012).

    Article  Google Scholar 

  16. Takeji, M. et al. J. Biol. Chem. 281, 40193–40200 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Allison A. Eddy is at the Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.,

    Allison A Eddy

Authors
  1. Allison A Eddy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Allison A Eddy.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eddy, A. The origin of scar-forming kidney myofibroblasts. Nat Med 19, 964–966 (2013). https://doi.org/10.1038/nm.3299

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3299

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing