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Obesity Notches up fatty liver

Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases (pages 1054–1060).

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Figure 1: Notch signaling in the liver during obesity.

Marina Corral Spence

References

  1. Brown, M.S. & Goldstein, J.L. Cell Metab. 7, 95–96 (2008).

    Article  CAS  Google Scholar 

  2. Pajvani, U.B. et al. Nat. Med. 19, 1054–1060 (2013).

    Article  CAS  Google Scholar 

  3. Perdigoto, C.N. & Bardin, A.J. Biochim. Biophys. Acta 1830, 2307–2322 (2013).

    Article  CAS  Google Scholar 

  4. Radtke, F. et al. Nat. Rev. Immunol. 13, 427–437 (2013).

    Article  CAS  Google Scholar 

  5. Han, M.S. et al. Science 339, 218–222 (2013).

    Article  CAS  Google Scholar 

  6. Pajvani, U.B. Nat. Med. 17, 961–967 (2011).

    Article  CAS  Google Scholar 

  7. Ricoult, S.J.H. & Manning, B.D. EMBO Rep. 14, 242–251 (2013).

    Article  CAS  Google Scholar 

  8. Um, S.H. et al. Nature 431, 200–205 (2004).

    Article  CAS  Google Scholar 

  9. Wan, M. et al. Cell Metab. 14, 516–527 (2011).

    Article  CAS  Google Scholar 

  10. Yecies, J.L. et al. Cell Metab. 14, 21–32 (2011).

    Article  CAS  Google Scholar 

  11. Biddinger, S.B. et al. Cell Metab. 7, 125–134 (2008).

    Article  CAS  Google Scholar 

  12. Liu, Z.J. et al. Atherosclerosis 225, 296–303 (2012).

    Article  CAS  Google Scholar 

  13. Fukuda, D. et al. Proc. Natl. Acad. Sci. USA 109, E1868–E1877 (2012).

    Article  CAS  Google Scholar 

  14. Purow, B. Adv. Exp. Med. Biol. 727, 305–319 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Michael P Czech.

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Czech, M. Obesity Notches up fatty liver. Nat Med 19, 969–971 (2013). https://doi.org/10.1038/nm.3293

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