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Obesity Notches up fatty liver

Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases (pages 1054–1060).

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Figure 1: Notch signaling in the liver during obesity.

Marina Corral Spence

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Correspondence to Michael P Czech.

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Czech, M. Obesity Notches up fatty liver. Nat Med 19, 969–971 (2013). https://doi.org/10.1038/nm.3293

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