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A step toward functionally characterized prostate cancer molecular subtypes

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ETS gene fusions and PTEN loss are common events in prostate cancer, but their interactions are not well understood. A new study in mice suggests that overexpression of ETS in the setting of PTEN loss increases androgen receptor binding and restores androgen receptor transcriptional activity (pages 1023–1029).

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Figure 1: The interactions between ETS and PTEN in prostate cancer.

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Correspondence to Francesca Demichelis or Gerhardt Attard.

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Demichelis, F., Attard, G. A step toward functionally characterized prostate cancer molecular subtypes. Nat Med 19, 966–967 (2013). https://doi.org/10.1038/nm.3285

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