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It takes nerves to recover from chemotherapy

Nature Medicine volume 19, pages 669–671 (2013)Cite this article

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Anticancer cytotoxic drugs also kill normal progenitors found in rapidly regenerating tissues, resulting in prolonged hematopoietic insufficiency. Chemotherapy-induced toxicity of the nerves that regulate bone marrow niches required for regeneration of hematopoietic stem cells (HSCs) is involved in this insufficiency, which suggests that co-administration of neuroprotective agents may protect HSCs from the toxic effects of drugs such as cisplatin and vincristine (pages 695–703).

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Figure 1: Detrimental effect of cisplatin and vincristine on innervation of HSC niches.

Katie Vicari

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  1. ingrid.winkler@mmri.mater.org.au

Authors and Affiliations

  1. Jean-Pierre Levesque and Ingrid G. Winkler are at Mater Research and University of Queensland, Woolloongabba, Queensland, Australia.,

    Jean-Pierre Levesque & Ingrid G Winkler

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  1. Jean-Pierre Levesque
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  2. Ingrid G Winkler
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Correspondence to Jean-Pierre Levesque or Ingrid G Winkler.

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Levesque, JP., Winkler, I. It takes nerves to recover from chemotherapy. Nat Med 19, 669–671 (2013). https://doi.org/10.1038/nm.3231

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