Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Stem Cell Research & Therapy Open Access 15 July 2021
-
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice
Scientific Reports Open Access 11 July 2018
-
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Bone Research Open Access 26 April 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Vicari
References
Berenbaum, F. Osteoarthritis Cartilage 21, 16–21 (2013).
Felson, D.T. Osteoarthritis Cartilage 21, 10–15 (2013).
Goldring, M.B. & Goldring, S.R. Ann. NY Acad. Sci. 1192, 230–237 (2010).
Zhen, G. et al. Nat. Med. 19, 704–712 (2013).
Janssens, K. et al. J. Med. Genet. 43, 1–11 (2006).
Felson, D.T. et al. Ann. Intern. Med. 134, 541–549 (2001).
Tang, Y. et al. Nat. Med. 15, 757–765 (2009).
Burr, D.B. & Gallant, M.A. Nat. Rev. Rheumatol. 8, 665–673 (2012).
Whyte, M.P. et al. J. Bone Miner. Res. 26, 920–933 (2011).
Serra, R. et al. J. Cell Biol. 139, 541–552 (1997).
Yang, X. et al. J. Cell Biol. 153, 35–46 (2001).
Blaney Davidson, E.N., van der Kraan, P.M. & van den Berg, W.B. Osteoarthritis Cartilage 15, 597–604 (2007).
van der Kraan, P.M. et al. Cell Tissue Res. 347, 257–265 (2012).
van Beuningen, H.M. et al. Lab. Invest. 71, 279–290 (1994).
Scharstuhl, A. et al. Arthritis Rheum. 48, 3442–3451 (2003).
Pitsillides, A.A. & Beier, F. Nat. Rev. Rheumatol. 7, 654–663 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Bush, J., Beier, F. TGF-β and osteoarthritis—the good and the bad. Nat Med 19, 667–669 (2013). https://doi.org/10.1038/nm.3228
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3228
This article is cited by
-
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Stem Cell Research & Therapy (2021)
-
The association of transforming growth factor beta 1 gene polymorphisms with arthritis: a systematic review and meta-analysis
Clinical and Experimental Medicine (2021)
-
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice
Scientific Reports (2018)
-
Differences in type II collagen turnover of osteoarthritic human knee and ankle joints
International Orthopaedics (2017)
-
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Bone Research (2016)
