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How antibiotics kill bacteria: new models needed?

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References

  1. Liu, Y. & Imlay, J.A. Cell death from antibiotics without the involvement of reactive oxygen species. Science 339, 1210–1213 (2013).

    Article  CAS  Google Scholar 

  2. Keren, I., Wu, Y., Inocencio, J., Mulcahy, L.R. & Lewis, K. Killing by bactericidal antibiotics does not depend on reactive oxygen species. Science 339, 1213–1216 (2013).

    Article  CAS  Google Scholar 

  3. Kohanski, M.A., Dwyer, D.J., Hayete, B., Lawrence, C.A. & Collins, J.J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130, 797–810 (2007).

    Article  CAS  Google Scholar 

  4. Foti, J.J., Devadoss, B., Winkler, J.A., Collins, J.J. & Walker, G.C. Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics. Science 336, 315–319 (2012).

    Article  CAS  Google Scholar 

  5. Wang, X., Zhao, X., Malik, M. & Drlica, K. Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J. Antimicrob. Chemother. 65, 520–524 (2010).

    Article  CAS  Google Scholar 

  6. Brook, I. Antimicrobial treatment of anaerobic infections. Expert Opin. Pharmacother. 12, 1691–1707 (2011).

    Article  CAS  Google Scholar 

  7. Hoskins, J. Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. 183, 5709–5717 (2001).

    Article  CAS  Google Scholar 

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How antibiotics kill bacteria: new models needed?. Nat Med 19, 544–545 (2013). https://doi.org/10.1038/nm.3198

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