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Blocking bleeding: reversing anticoagulant therapy

A new generation of target-specific inhibitors of the coagulation enzymes thrombin and factor Xa has been approved for a number of indications, but the clinical use of these drugs is hindered by the lack of a way to reverse bleeding, should it occur. An antidote to these new oral anticoagulants has now been designed and shows promise in small-animal models of blood loss (pages 446–451).

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Figure 1: Lu et al.11 now describe the design and actions of an antidote to target-specific anticoagulants.

Katie Vicari


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Correspondence to Jack Ansell.

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J.A. is a member of the scientific advisory board of and owns equity in Perosphere.

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Ansell, J. Blocking bleeding: reversing anticoagulant therapy. Nat Med 19, 402–404 (2013).

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