A new generation of target-specific inhibitors of the coagulation enzymes thrombin and factor Xa has been approved for a number of indications, but the clinical use of these drugs is hindered by the lack of a way to reverse bleeding, should it occur. An antidote to these new oral anticoagulants has now been designed and shows promise in small-animal models of blood loss (pages 446–451).
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J.A. is a member of the scientific advisory board of and owns equity in Perosphere.
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Ansell, J. Blocking bleeding: reversing anticoagulant therapy. Nat Med 19, 402–404 (2013). https://doi.org/10.1038/nm.3157
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DOI: https://doi.org/10.1038/nm.3157
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