Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Exploring the erythroblastic island

Two new studies suggest a crucial role for macrophages in boosting the number of red blood cells produced in vivo during stress, with translational implications for disease states such as β-thalassemia and polycythemia vera (pages 429–436 and 437–445).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Erythropoiesis within and without the erythroblastic island.

Katie Vicari


  1. Koury, M.J. & Bondurant, M.C. Science 248, 378–381 (1990).

    Article  CAS  Google Scholar 

  2. Koulnis, M., Liu, Y., Hallstrom, K. & Socolovsky, M. PLoS ONE 6, e21192 (2011).

    Article  CAS  Google Scholar 

  3. Manwani, D. & Bieker, J.J. Curr. Top. Dev. Biol. 82, 23–53 (2008).

    Article  CAS  Google Scholar 

  4. Mohandas, N. & Chasis, J.A. Transfus. Clin. Biol. 17, 110–111 (2010).

    Article  Google Scholar 

  5. Chow, A. et al. Nat. Med. 19, 429–436 (2013).

    Article  CAS  Google Scholar 

  6. Ramos, P. et al. Nat. Med. 19, 437–445 (2013).

    Article  CAS  Google Scholar 

  7. McGrath, K.E., et al. Blood 111, 2409–2417 (2008).

    Article  CAS  Google Scholar 

  8. Sorrell, J.M. & Weiss, L. Am. J. Anat. 164, 57–66 (1982).

    Article  CAS  Google Scholar 

  9. Socolovsky, M. et al. PLoS Biol. 5, e252 (2007).

    Article  Google Scholar 

  10. Rhodes, M.M., Kopsombut, P., Bondurant, M.C., Price, J.O. & Koury, M.J. Blood 111, 1700–1708 (2008).

    Article  CAS  Google Scholar 

  11. Leimberg, M.J., Prus, E., Konijn, A.M. & Fibach, E. J. Cell. Biochem. 103, 1211–1218 (2008).

    Article  CAS  Google Scholar 

  12. Ulyanova, T., Jiang, Y., Padilla, S., Nakamoto, B. & Papayannopoulou, T. Blood 117, 975–985 (2011).

    Article  CAS  Google Scholar 

  13. Sadahira, Y. et al. J. Leukoc. Biol. 68, 464–470 (2000).

    CAS  PubMed  Google Scholar 

  14. Li, H. et al. Nat. Med. 16, 177–182 (2010).

    Article  CAS  Google Scholar 

  15. Gardenghi, S. et al. J. Clin. Invest. 120, 4466–4477 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Merav Socolovsky.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Socolovsky, M. Exploring the erythroblastic island. Nat Med 19, 399–401 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing