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Coagulation factor defends adenovirus from immune attack

Adenovirus type 5 (Ad5) has been intensively studied as a viral vector for gene therapy, and understanding host–Ad5 interactions will be key to the safe and effective use of this vector. A recent study in mice provides new insights in this area by showing that Ad5 enlists a host coagulation factor to overcome complement-mediated blockade and infect the liver (pages 452–457).

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Figure 1: Adenovirus liver tropism is regulated by interactions with FX.

Katie Vicari


  1. Raper, S.E. et al. Mol. Genet. Metab. 80, 148–158 (2003).

    Article  CAS  Google Scholar 

  2. Xu, Z. et al. Nat. Med. 19, 452–457 (2013).

    Article  CAS  Google Scholar 

  3. Wickham, T.J. et al. Cell 73, 309–319 (1993).

    Article  CAS  Google Scholar 

  4. Kalyuzhniy, O. et al. Proc. Natl. Acad. Sci. USA 105, 5483–5488 (2008).

    Article  CAS  Google Scholar 

  5. Waddington, S.N. et al. Cell 132, 397–409 (2008).

    Article  CAS  Google Scholar 

  6. Shayakhmetov, D.M. et al. J. Virol. 79, 7478–7491 (2005).

    Article  CAS  Google Scholar 

  7. Smith, T.A. et al. Hum. Gene Ther. 14, 777–787 (2003).

    Article  CAS  Google Scholar 

  8. Cooper, N.R. & Nemerow, G.R. Springer Semin. Immunopathol. 6, 327–347 (1983).

    Article  CAS  Google Scholar 

  9. Xu, Z. et al. J. Virol. 82, 11705–11713 (2008).

    Article  CAS  Google Scholar 

  10. Khare, R. et al. J. Virol. 86, 2293–2301 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Glen R Nemerow.

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Nemerow, G. Coagulation factor defends adenovirus from immune attack. Nat Med 19, 406–407 (2013).

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