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Love the one you're with: the HIV, B cell and TFH cell triangle

Many HIV-infected people show impaired humoral immune responses, but it is unclear why. A new view into this conundrum may be provided with the recent discovery of altered interactions between follicular helper T (TFH) cells and germinal center B cells from HIV-infected individuals. This leads to inadequate TFH cell help for germinal center B cells and decreased B cell antibody responses (pages 494–499).

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Figure 1: PD-1 signaling between germinal center B cells and TFH cells in HIV infection impairs B cell immunity.

Katie Vicari


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Correspondence to Shiv Pillai.

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Pillai, S. Love the one you're with: the HIV, B cell and TFH cell triangle. Nat Med 19, 401–402 (2013).

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